Du sökte efter: Formamidine+disulphide+dihydrochloride

Artikel nummer : (BOSSBS-4250R-CY7)

Leverantör: Bioss

Beskrivning: The three dimensional structure of many extracellular proteins is stabilized by the formation of disulphide bonds. Studies suggest that a microsomal enzyme known as Protein Disulphide Isomerase (PDI) is involved in disulphide-bond formation and isomerization, as well as the reduction of disulphide bonds in proteins. PDI, which catalyses disulphide interchange between thiols and protein dilsulphides, has also been referred to as thiol:protein-disulphide oxidoreductase and as glutathione:insulin transhydrogenase because of its role in reduction of disulphide bonds. The highly conserved sequence Lys-Asp-Glu-Leu (KDEL) is present at the carboxy-terminus of PDI and other soluble endoplasmic reticulum (ER) resident proteins including the 78 and 94 kDa glucose regulated proteins (GRP78 and GRP94 respectively). The presence of carboxy-terminal KDEL appears to be necessary for ER retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor.

UOM: 1 * 100 µl

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Leverantör: Thermo Fisher Scientific

Beskrivning: 2,2'-Dithiodianiline (thulium ionophore I) 97%

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Leverantör: Thermo Fisher Scientific

Beskrivning: Disulfiram 97%

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Leverantör: Thermo Fisher Scientific

Beskrivning: Selendisulfid ≥97%

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Leverantör: TCI

Beskrivning: Cystamine sulphate hydrate ≥98.0%

Leverantör: TCI

Beskrivning: 2-Methyl-3-(methyldithio)furan ≥98.0%

Artikel nummer : (39785.AY)

Leverantör: Thermo Fisher Scientific

Beskrivning: Koldisulfid ≥99.9% ACS

UOM: 1 * 4 Items

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Leverantör: Thermo Fisher Scientific

Beskrivning: Disulfiram ≥97%

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Leverantör: Thermo Fisher Scientific

Beskrivning: Titanium(IV) sulphide ≥99.8%

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Leverantör: Thermo Fisher Scientific

Beskrivning: Molybden(IV)sulfid ≥98%

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Leverantör: Apollo Scientific

Beskrivning: Disulfiram

Leverantör: Thermo Fisher Scientific

Beskrivning: Selendisulfid ≥94%

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Leverantör: ENZO LIFE SCIENCES

Beskrivning: The mammalian protein disulphide-isomerase (PDI) family encompasses several highly divergent proteins involved in the processing and maturation of secretory proteins in the ER by catalyzing the rearrangement of disulphide bonds. PDI, an abundant protein of the ER (>400uM), contains a carboxy-terminal retention signal sequence, KDEL, similar to that of BiP and Grp94. The PDI proteins are characterized by the presence of one or more domains of ~95-110 amino acids related to the cytoplasmic protein thioredoxin. All but the PDI-D subfamily are composed entirely of repeats of such domains, with at least one domain containing - and one domain lacking - a redox-active-Cys-X-X-Cys-tetrapeptide. In addition to roles as redox catalysts and isomerases, PDI proteins perform such functions as peptide binding and cell adhesion, and may conduct chaperone activities. Platelet surface thiols and disulphides play an important role in platelet responses. Catalytically active PDI resides on platelet surfaces where it mediates platelet aggregation and secretion by reducing disulfide bonds, thus exposing fibrinogen receptors in platelets.

New Product

Artikel nummer : (TCIAD3670-1G)

Leverantör: TCI

Beskrivning: 4,4'-Dithiodibutyric acid ≥99.0% (by GC, titration analysis)

UOM: 1 * 1 g

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Leverantör: Thermo Fisher Scientific

Beskrivning: Tiram 97%

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Leverantör: TCI

Beskrivning: Lawesson's reagent ≥95.0% sulphurating reagent