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Ruthenium(III) nitrosylnitrate I utspädd salpetersyralösning (vattenlösning)

Leverantör: Thermo Fisher Scientific

Beskrivning: Appearance: Clear orange to dark brown Solution

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Bly(II)nitrat ACS

Leverantör: Thermo Fisher Scientific

Beskrivning: Bly(II)nitrat ACS

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Bly(II)nitrat ≥99.0% ACS, Fluka™

Leverantör: Honeywell Chemicals

Beskrivning: Bly(II)nitrat ≥99.0% ACS, Fluka™

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Bly(II)nitrat ≥99%

Leverantör: Thermo Fisher Scientific

Beskrivning: Bly(II)nitrat ≥99%

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Lead standard solution (0.1% Pb) Reag. Ph. Eur. 5001700

Artikel nummer : (88087.180)

Leverantör: VWR Chemicals

Beskrivning: Lead standard solution (0.1% Pb) Reag. Ph. Eur. 5001700

UOM: 1 * 100 mL

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Ruthenium(III) nitrosylnitrate lösning (1,5% Ru) (w/v)

Leverantör: Thermo Fisher Scientific

Beskrivning: Ruthenium(III) nitrosylnitrate lösning (1,5% Ru) (w/v)

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Bly(II)nitrat 99+%

Leverantör: Thermo Fisher Scientific

Beskrivning: Bly(II)nitrat 99+%

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Nitrite CRM, standard solutions, Supelco®

Leverantör: Merck

Beskrivning: Nitrite standard solution, 40,0 mg/L NO₂-N, Supelco®, Innehåller: NaNO₂ in H₂O, För testkit: 1.00609

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Anti-SNCA Rat Monoclonal Antibody

Leverantör: ENZO LIFE SCIENCES

Beskrivning: Synuclein was originally identified in Torpedo californica as a small neuroprotein that localized to the nuclear envelope of neurons and to presynaptic nerve termini. The human homolog was initially termed NACP, a precursor protein to NAC (Non-Ab Component), because of its prevalence in amyloid plaques in Alzheimer’s patients. Later, NACP was recognized as being alpha-Synuclein (alpha-SYN), a 14kDa protein, belonging to the synuclein family of phosphoproteins that also includes: betalpha-SYNuclein, gammalpha-SYNuclein, and synoretin.
alpha-SYN is recognized as a key component in the development and diagnosis of neurodegenerative synucleinopathic diseases (NSDs), such as Alzheimer’s and Parkinson’s disease. In the past five years, several genetic and post-translational modifications to alpha-SYN have been elucidated that have been linked to its collaboration in the formation of the classical Lewy bodies (LBs) or Lewy neurites that are associated with neurodegeneration. A study that shed more light on the neurogenesis of autorecessive synucleinopathies (ARSs) was the finding that alpha-SYN accumulation can occur due to mutations in the E3 ubiquitin ligase.
ARSs only account for a small percentage of NSD. Thus the illustration that alpha-SYN has a high susceptibility to tyrosine nitration may be the key component in understanding the formation of LBs. Due to the chemical structure of alpha-SYN, tyrosine nitration readily leads to the formation of oligomers via covalent O,O’-dityrosine bonds (cross-linking). Nitrosylated, wild-type, alpha-SYN products thus form SDS-insoluble, heat-stable aggregates in vitro that may account for alpha-SYN inclusions in all forms of NSDs.

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Bly(II)nitrat ≥99%, Puriss., Fluka™

Leverantör: Honeywell Chemicals

Beskrivning: Bly(II)nitrat ≥99%, Puriss., Fluka™

Peroxynitrite Na i natriumhydroxidlösning

Artikel nummer : (CAYM81565-1)

Leverantör: Cayman Chemical

Beskrivning: Peroxynitrite is formed in vivo by the reaction of NO with superoxide. It is a powerful oxidizing agent that can initiate lipid peroxidation, oxidize sulfhydryls, and nitrate the aromatic residues of proteins.

UOM: 1 * 1 mL

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