Du sökte efter: STEMCELL Technologies

Artikel nummer : (STMC100-1407)

Leverantör: STEMCELL Technologies

Beskrivning: Stimulating T cells with Candida (MP65) peptide pool releases downstream cytokines and upregulates activation markers, enabling antigen-specific T cells to be detected or isolated for analysis. Candida peptide pool is a lyophilised mixture of 92 peptides from the mannoprotein MP65 of Candida albicans (yeast), and consists of 15-mer peptides with 11-amino-acid overlaps that cover amino acids 1 to 379 on MP65. MP65 contributes to cell wall integrity and epithelia adherence (Sandini <i>et al.</i>), and is a potent T cell immunogen (Gomez <i>et al.</i>). Viral peptide pools are useful for a broad range of applications, including vaccine development, immunological research, and diagnostic assay development.

UOM: 1 * 1 EEnh

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Leverantör: STEMCELL Technologies

Beskrivning: The principal physiological regulator of erythropoiesis, Erythropoietin (EPO) is a glycoprotein growth factor that is produced primarily in the kidney in response to hypoxia or anemia. EPO promotes erythropoiesis by binding to a homodimeric cell surface receptor that activates JAK2/STAT5, PI3K/AKT, and MAPK pathways, and stimulates the proliferation and differentiation of erythroid progenitor cells (Jelkmann. Transfus Med Hemother, 2013; Kuhrt and Wojchowski. Blood, 2015).

Leverantör: STEMCELL Technologies

Beskrivning: Betacellulin is a member of the epidermal growth factor (EGF) family, and signals through EGF receptor and ERBB4. It activates ERK and AKT pathways, which induces neural stem cell proliferation and prevents spontaneous differentiation in culture. Betacellulin stimulates the expansion of neural stem cells, transit-amplifying cells, and neuroblasts derived from subventricular zone and dentate gyrus (Gómez-Gaviro <i>et al.</i>). It is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. Betacellulin down-regulates E-cadherin expression in ovarian cancer cell lines via MEK/ERK1/2 and PI3K/AKT signaling pathways, thus increasing cell migration (Zhao <i>et al.</i>). It is a modulator of interferon (IFN) response and enhances anti-viral effects of IFN (Al-Yahya <i>et al.</i>). Betacellulin is expressed in pancreatic α cells, β cells, and duct cells. It induces the proliferation of pancreatic cancer cell lines, inhibits apoptosis, promotes the neogenesis of β cells, and converts non-β cells into insulin-producing cells (Kawaguchi <i>et al.</i>; Miyagawa al.; Saito <i>et al.</i>).

Leverantör: STEMCELL Technologies

Beskrivning: Stromal cell-derived factor 1 alpha (SDF-1α) is a member of the CXC group of chemokines that binds to the G-protein coupled receptor, CXCR4, to regulate migration, proliferation, differentiation, and survival of many cell types including hematopoietic stem cells, B cells, and T cells. It is produced by bone marrow stromal cells, osteoblasts, endothelial cells, and neuronal cells. SDF-1α was first identified as the pre-B-cell growth-stimulating factor (PBSF) in the mouse bone marrow-derived stromal cell line, PA6, in the growth of B cell precursors (Hayashi <i>et al.</i>). SDF-1α primarily regulates cell motility during development and adulthood, including the homing of hematopoietic stem cells and neutrophils to fetal bone marrow during ontogeny (Ara <i>et al.</i> 2003a) and the recruitment of endothelial progenitor cells from bone marrow during angiogenesis in adulthood (Zheng <i>et al.</i>). In addition to its role in hematopoiesis, the SDF-1α/CXCR4 signaling pathway is also essential for the homing of primordial germ cells to gonads (Ara <i>et al.</i> 2003b), the migration of granule cells in the cerebellum during neurogenesis (Zou <i>et al.</i>), and the migration of breast cancer cells to sites of metastasis (Muller <i>et al.</i>).

Leverantör: STEMCELL Technologies

Beskrivning: Vascular endothelial growth factor (VEGF-121) is a naturally-occurring VEGF-A splice variant involved in embryonic vasculogenesis and angiogenesis. VEGF binds to VEGFR-1 and VEGFR-2, and activates Raf/MEK/ERK and PI3K/AKT pathways. VEGF-121 is released as a freely diffusible protein by a variety of normal and transformed cells. It plays an important role in neurogenesis both in vitro and in vivo (Storkebaum <i>et al.</i>). It has neurotrophic effects on neurons of the central nervous system and promotes growth and survival of dopaminergic neurons and astrocytes. VEGF also promotes growth and survival of vascular endothelial cells, monocyte chemotaxis, and colony formation by granulocyte-macrophage progenitor cells (Ferrara <i>et al.</i>).

Leverantör: STEMCELL Technologies

Beskrivning: Immunomagnetic isolation of untouched human naïve CD4+ T cells.

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Artikel nummer : (STMC60003AZ.1)

Leverantör: STEMCELL Technologies

Beskrivning: Mouse monoclonal IgG1 antibody against human, rhesus, cynomolgus CD138 (syndecan-1), APC-conjugated.

UOM: 1 * 25 Tests

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Artikel nummer : (STMC04564)

Leverantör: STEMCELL Technologies

Beskrivning: Complete kit for hematopoietic CFU assays.

UOM: 1 * 1 KIT

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Leverantör: STEMCELL Technologies

Beskrivning: Serum-free medium for culture and expansion of hematopoietic cells.

Artikel nummer : (STMC07905)

Leverantör: STEMCELL Technologies

Beskrivning: Dulbecco's Phosphate Buffered Saline with 2% fetal bovine serum is recommended for use as a buffer to dilute or wash nucleated cells.

UOM: 1 * 500 mL

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Artikel nummer : (STMC02696)

Leverantör: STEMCELL Technologies

Beskrivning: Serum-free culture supplement for expansion of human megakaryocytes.

UOM: 1 * 1 mL

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Leverantör: STEMCELL Technologies

Beskrivning: Medium for the culture and differentiation of human monocytes into dendritic cells and their maturation.

Artikel nummer : (STMC03820)

Leverantör: STEMCELL Technologies

Beskrivning: Animal component-free, serum-free, glutamine-free 40X supplement for cloning during CHO cell line development.

UOM: 1 * 2,5 mL

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Leverantör: STEMCELL Technologies

Beskrivning: Mouse monoclonal IgG2b antibody against human, rhesus, cynomolgus CD4, FITC-conjugated.

Leverantör: STEMCELL Technologies

Beskrivning: Mouse monoclonal IgG1 antibody against human, rhesus, cynomolgus CD83, APC-conjugated.

Leverantör: STEMCELL Technologies

Beskrivning: Mouse monoclonal IgG1 antibody against human, rhesus, cynomolgus CD90 (Thy-1), PerCP-Cy5.5-conjugated.