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Leverantör: ENZO LIFE SCIENCES
Beskrivning: Isolated from Salmonella typhimurium strain 14028.

Leverantör: ENZO LIFE SCIENCES
Beskrivning: Produced in <i>E. coli</i>.

Leverantör: ENZO LIFE SCIENCES
Beskrivning: Sterile and endotoxin-free PBS for use with TLRgrade™ or endotoxin-free grade reagents.

Artikel nummer : (ENZOALX804510C100)
Leverantör: ENZO LIFE SCIENCES
Beskrivning: The GST Family
Glutathione S-transferases (GSTs) are a large multigen family of multifunctional enzymes, which play an important role in detoxification of potentially genotoxic chemicals, by catalyzing the conjugation of glutathione to a large number of hydrophobic and electrophilic compounds, including carcinogens. They also bind to a variety of nonsubstrate ligands. The GSTs are widely distributed in mammalian species and can be grouped into four classes, based on their biochemical, immunological and structural properties: alpha, mu, pi and theta.

GSTs are dimeric, mainly cytosolic, enzymes that have extensive ligand binding properties in addition to their catalytic role in detoxification. A separate microsomal class of GSTs exists which is quite distinct from the cytosolic GSTs, and is designated as "membrane-associated proteins in eicosanoid and glutathione metabolism" (MAPEG). The N-terminal region tends to be better conserved within classes as it includes an important part of the active site.GSTs are believed to play a role in cancer prevention, as the electrophilic compounds that are conjugated to glutathione could otherwise react with and modify cellular components such as DNA, thereby initiating carcinogenesis. On the other hand, GSTs might detoxify chemotherapeutic drugs in cancer cells, thus contributing to drug resistance.
In summary, GSTs are a group of enzymes which are centrally involved in drug metabolism and detoxification. Because of their role in detoxification, they have been implicated in drug sensitivity and resistance. They may also influence mutagenesis and carcinogenesis and thus, increased GST activity may become a useful cancer marker.
Since many GST genes are polymorphic, there has been considerable interest in determining whether particular allelic variants are also associated with an increase of risk for certain diseases.

Glutathione S-transferase-Pi
The GST-Pi class (phase II detoxification enzymes) is the most abundant of the human glutathione S-transferases family, a major group of detoxification enzymes and widely distributed in the human body.
In normal human tissues, the enzymes protect cells against reactions with glutathione and reactive oxygen species by reducing organic hydroperoxides via gluthathione peroxidase activity.
The role of GST-Pi in tumor growth and progression is less well known. It is reported to be variably expressed in breast cancer and is associated with estrogen receptor levels expressed by the tumor. Down-regulation of GST-Pi activity in a study done on a T cell line appears to favor apoptosis and inhibition of GST-Pi function induces apoptosis in rat hepatoma cells.
The importance in cancer research is clear, as GST-Pi has been implicated in protection against apoptosis and also suggested to have a role in jun kinase inhibition.
The majority of human tumor cell lines express significant amounts of class pi GST, which is why it is being investigated as a potential marker for various types of cancer. GST-Pi is thought to be associated with increased resistance to anticancer drugs. GST-Pi expression is under investigation as a prognostic indicator for resistance to chemotherapy and a marker of treatment resistance.
UOM: 1 * 100 µG


Artikel nummer : (ENZOADI905110500)
Leverantör: ENZO LIFE SCIENCES
Beskrivning: Interleukin-8 (IL-8) is a cytokine produced by monocytes, macrophages, neutrophils, lymphocytes, dermal fibroblasts, keratinocytes, vascular endothelial cells, melanocytes, hepatocytes and various tumor cell lines. It is also a member of the CXC family of chemokines, displaying chemotactic activity for neutrophils and T cells.
UOM: 1 * 500 µG


Artikel nummer : (ENZOALX350362M025)
Leverantör: ENZO LIFE SCIENCES
Beskrivning: First phthalideisoquinoline hemiacetal from a natural source. Inhibits Ca²⁺ currents and contractile responses in vitro.
UOM: 1 * 25 mg


Leverantör: ENZO LIFE SCIENCES
Beskrivning: SCREEN-WELL® Fatty Acid Library contains 64 fatty acids of varying saturation and chain length.

Artikel nummer : (ENZOADI900135)
Leverantör: ENZO LIFE SCIENCES
Beskrivning: For the quantitative determination of β-Catenin in cell lysates of human, mouse, and rat origin.
UOM: 1 * 1 KIT


Artikel nummer : (ENZOBMLSE3010025)
Leverantör: ENZO LIFE SCIENCES
Beskrivning: Isolated from Streptomyces chromofuscus.
UOM: 1 * 25 KU


Artikel nummer : (ENZOALX480019M010)
Leverantör: ENZO LIFE SCIENCES
Beskrivning: DNA alkyltransferase substrate and inhibitor
UOM: 1 * 10 mg


Leverantör: ENZO LIFE SCIENCES
Beskrivning: LYSO-ID® Green Detection Kit is an acidic organelle-selective dye specially designed to use with RFP-expressing cell lines, as well as cells expressing blue, cyan or orange fluorescent proteins (BFPs, CFPs, OFPs).

Artikel nummer : (ENZOBMLPD1800010)
Leverantör: ENZO LIFE SCIENCES
Beskrivning: Ultrapotent, highly selective inhibitor of cGMP-inhibited phosphodiesterase (PDE lll, IC50=0.3nM) in vitro. Potentiates adenosine-stimulated cAMP accumulation.
UOM: 1 * 10 mg


Artikel nummer : (ENZOBMLP2430001)
Leverantör: ENZO LIFE SCIENCES
Beskrivning: This peptide, Biotin-Ahx-GGMEDIYFEFMGGKKK, identified by screening a degenerate peptide library, is a substrate for several kinases, including HER-2/c-neu/erb-B-2, Tie-2, cFMS, and cKit.
UOM: 1 * 1 mg


Artikel nummer : (ENZOENZCHM1260001)
Leverantör: ENZO LIFE SCIENCES
Beskrivning: Selective inhibitor of Akt (PKB).
UOM: 1 * 1 mg


Leverantör: ENZO LIFE SCIENCES
Beskrivning: Potent inhibitor of phosphatidic acid generation

Leverantör: ENZO LIFE SCIENCES
Beskrivning: Cyclic GMP-dependent protein kinases (PKGs or cGKs) are classified into two types, PKGI and PKGII. Studies have shown that PKGs are highly homologous to PKAs; phosphorylation of cellular proteins by both families of kinases leads to alterations in calcium mobilization, protein phosphatase activity, ion channel function, gene transcription, smooth muscle contractility, and platelet aggregation.

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Lager för denna produkt är begränsat, men kan vara tillgänglig i ett lager nära dig. Se till att du är inloggad på hemsidan så att tillgängligt lager kan visas. Om call fortfarande visas och du behöver hjälp, ring oss på 08-621 34 20.
VWR International AB säljer bara etanol till skattebefriade kunder. Denna produkt ä reglerad enligt svensk lagstiftning. Om ytterligare information krävs av dig kommer du att kontaktas via e-post.
VWR International AB säljer bara etanol till skattebefriade kunder.
Denna produkt ä reglerad enligt svensk lagstiftning. Om ytterligare information krävs av dig kommer du att kontaktas via email.
Produkten har blockerats av din organisation. Vänligen kontakta din inköpsavdelning för mer information.
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