Du sökte efter: Bioss

Artikel nummer : (BOSSBS-13218R)

Leverantör: Bioss

Beskrivning: Anti-FZD6 Rabbit Polyclonal Antibody

UOM: 1 * 100 µl

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Artikel nummer : (BOSSBS-1220R)

Leverantör: Bioss

Beskrivning: Testis and spermatogenesis related gene 4 may play a role in the development of cryptorchidism, the failure of the testis to descend from the abdomen into the scrotum [RGD] [TISSUE SPECIFICITY] Testis.

UOM: 1 * 100 µl

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Artikel nummer : (BOSSBS-1366R)

Leverantör: Bioss

Beskrivning: Anti-NF2 Rabbit Polyclonal Antibody

UOM: 1 * 100 µl

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Artikel nummer : (BOSSBS-1330R)

Leverantör: Bioss

Beskrivning: Anti-PLEKHO1 Rabbit Polyclonal Antibody

UOM: 1 * 100 µl

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Artikel nummer : (BOSSBS-1361R)

Leverantör: Bioss

Beskrivning: Anti-DDIT3 Rabbit Polyclonal Antibody

UOM: 1 * 100 µl

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Artikel nummer : (BOSSBS-1412R)

Leverantör: Bioss

Beskrivning: Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator. As a part of the histone-deacetylase multiprotein complex (NuRD), regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA. In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A. Acts as a transcriptional coactivator of BCAS3, PAX5 and SUMO2, independent of the NuRD complex. Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3. Plays a role in the inflammatory responses, both as a target and as a component of the NF-kappa-B signaling and regulates a subset of proinflammatory cytokines such as IL1B, MIP2, and TNF. Regulates p53-dependent and -independent DNA repair processes following genotoxic stress. Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair. Plays an important role in tumorigenesis, tumor invasion, and metastasis. Involved in the epigenetic regulation of ESR1 expression in breast cancer in a TFAP2C, IFI16 and HDAC4/5/6-dependent manner. Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles. Positively regulates the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1. Regulates deacetylation of ARNTL/BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1-mediated transcription repression. Isoform Short binds to ESR1 and sequesters it in the cytoplasm and enhances its non-genomic responses.

UOM: 1 * 100 µl

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Artikel nummer : (BOSSBS-1481R)

Leverantör: Bioss

Beskrivning: Mediates B-cell B-cell interactions. May be involved in the localisation of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.

UOM: 1 * 100 µl

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Artikel nummer : (BOSSBS-1346R)

Leverantör: Bioss

Beskrivning: Anti-TRP73 Rabbit Polyclonal Antibody

UOM: 1 * 100 µl

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Artikel nummer : (BOSSBS-1504R)

Leverantör: Bioss

Beskrivning: Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localisation to microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions.

UOM: 1 * 100 µl

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Artikel nummer : (BOSSBS-1503R)

Leverantör: Bioss

Beskrivning: This gene belongs to the cytokine gene family which encode secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC (Cys-X-Cys) subfamily of cytokines. Members of this subfamily are characterised by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes but not for lymphocytes, dendritic cells, neutrophils or macrophages. It has been implicated that this cytokine is involved in the homeostasis of monocyte-derived macrophages rather than in inflammation. [FUNCTION] Potent chemoattractant for neutrophils, and weaker for dendritic cells. Not chemotactic for T-cells, B-cells, monocytes, natural killer cells or granulocytes. Does not inhibit proliferation of myeloid progenitors in colony formation assays.

UOM: 1 * 100 µl

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Artikel nummer : (BOSSBS-1389R)

Leverantör: Bioss

Beskrivning: May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (By similarity).

UOM: 1 * 100 µl

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Artikel nummer : (BOSSBS-1471R)

Leverantör: Bioss

Beskrivning: The Annexin family of calcium binding proteins is composed of at least ten mammalian genes. It is characterised by a conserved core domain which binds to phospholipids in a Ca2+ dependent manner and a unique amino terminal region which may confer binding specificity. The Annexin family has been implicated as regulators of such diverse processes as ion flux, endocytosis and exocytosis, and cellular adhesion. When overexpressed in A431 cells, Annexin VI causes a partial reversal of the transformed phenotype.

UOM: 1 * 100 µl

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Artikel nummer : (BOSSBS-1433R)

Leverantör: Bioss

Beskrivning: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyse the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis.

UOM: 1 * 100 µl

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Artikel nummer : (BOSSBS-1600R)

Leverantör: Bioss

Beskrivning: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.

UOM: 1 * 100 µl

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Artikel nummer : (BOSSBS-3291R)

Leverantör: Bioss

Beskrivning: Anti-NF2 Rabbit Polyclonal Antibody

UOM: 1 * 100 µl

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Artikel nummer : (BOSSBS-3731R)

Leverantör: Bioss

Beskrivning: Anti-NOS3 Rabbit Polyclonal Antibody

UOM: 1 * 100 µl

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