Mouse monoclonal IgG1 antibody against human SSEA-5, APC-conjugated.
The 8e11 antibody reacts with stage-specific embryonic antigen-5 (SSEA-5), a terminal H type-1 glycan (Fuc1-2Galβ1-3GlcNAcβ1) expressed on the surface of cells in the inner cell mass of the human blastocyst during embryogenesis, and on undifferentiated human embryonic stem (ES) and induced pluripotent stem (iPS) cells. Expression of SSEA-5 is rapidly down-regulated upon cellular differentiation. The 8e11 antibody can be used in conjunction with other pluripotency surface markers such as CD9 and CD90, or CD50 and CD200, to sort and remove undifferentiated teratoma-forming cells from incompletely differentiated stem cell cultures.
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Type:
Antigen: SSEA-5
Clonality: Monoclonal
Clone: 8E11
Conjugation: APC
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Human