Anti-CD8a Mouse Monoclonal Antibody [clone: RPA-T8] (PE)

Leverantör: STEMCELL Technologies
60022PE 60022PE.1
STMC60022PEEA 2168 SEK
STMC60022PE STMC60022PE.1
Anti-CD8a Mouse Monoclonal Antibody [clone: RPA-T8] (PE)
Antikroppar
Mouse monoclonal IgG1 antibody against human, rhesus, cynomolgus CD8a, PE-conjugated.

  • T cells
  • T cells CD8

The RPA-T8 antibody reacts with CD8a, a 32 - 34 kDa type I transmembrane glycoprotein which is a subunit of CD8. CD8 is a disulfide-bonded dimer, found either as a heterodimer of CD8a (α) and CD8b (β) subunits (i.e., αβ) or a homodimer (αα). CD8 acts as a co-receptor to the T cell receptor (TCR) during T cell activation by binding MHC Class I molecules presented by an antigen-presenting cell. It functions to strengthen the association between the TCR and MHC I-antigen complex, and to amplify signals from the TCR to the cytoplasm through the interaction of its intracellular domain with cytoplasmic tyrosine kinases such as Lck. The CD8a chain binds to the α3 domain of class I MHC molecules. CD8 is expressed by a majority of thymocytes, a subset of mature peripheral blood T cells (T cytotoxic cells), a proportion of β T cells, and at lower levels by NK cells (which predominantly express CD8a homodimers). This antibody clone has been verified for purity assessments of cells isolated with EasySep™ kits, including EasySep™ Direct Human CD8+ T Cell Isolation Kit (Catalog #19663), EasySep™ Human CD8+ T Cell Enrichment Kit (Catalog #19053), EasySep™ Human CD8 Positive Selection Kit (Catalog #18053), EasySep™ Human CD3 Positive Selection Kit (Catalog #18051), EasySep™ HLA CD2 Positive Selection Kit (Catalog #18657HLA), and EasySep™ HLA T Cell Enrichment Kit (Catalog #19051HLA).

Observera: Product restrictions: (i) Customer shall not make products or any portion of them in any way, shape or form, including as a component of another product available for the purpose of further resale or alter or remove the Product label and the Supplier’s mark of origin without express written permission of Supplier and (ii) Customer is familiar with Supplier’s restrictions on the use of the products and shall use the products in compliance with such restrictions and the applicable Supplier Product Information sheet (collectively, the 'Product Restrictions').

Type:
Antigen: CD8a
Clonality: Monoclonal
Clone: RPA-T8
Conjugation: PE
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Baboon, Chimpanzee, Cynomolgus monkey, Human, Macaque, Rhesus monkey, Sooty mangabey
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