Anti-CD54 (ICAM-1) Rat Monoclonal Antibody [clone: YN1/1.7.4]

Leverantör: STEMCELL Technologies
60151 60151.1
STMC60151EA 2872 SEK
STMC60151 STMC60151.1
Anti-CD54 (ICAM-1) Rat Monoclonal Antibody [clone: YN1/1.7.4]
Antikroppar
Rat monoclonal IgG2b antibody against mouse CD54, unconjugated.

  • Endothelial cells

The YN1/1.7.4 antibody reacts with CD54, a 90 - 110 kDa type I transmembrane glycoprotein that is a member of the immunoglobulin (Ig) superfamily. CD54 consists of five Ig-like C2 type domains and has two isoforms generated from alternative splicing. As an important intercellular adhesion molecule, CD54 is involved in inflammatory reactions, antigen-specific immune responses, lymphocyte trafficking, and T cell signal transduction events. CD54 mediates important cell-cell interactions and adhesion reactions by binding to its major ligands, LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). CD54 may also act as a receptor for rhinoviruses and some coxsackieviruses. CD54 is expressed on lymphocytes, monocytes, macrophages, dendritic cells, endothelial cells, and high endothelial venules. Expression of CD54 is upregulated on activated lymphocytes and also, following stimulation with inflammatory mediators such as cytokines, LPS, and IFN-γ.

Observera: Product restrictions: (i) Customer shall not make products or any portion of them in any way, shape or form, including as a component of another product available for the purpose of further resale or alter or remove the Product label and the Supplier’s mark of origin without express written permission of Supplier and (ii) Customer is familiar with Supplier’s restrictions on the use of the products and shall use the products in compliance with such restrictions and the applicable Supplier Product Information sheet (collectively, the 'Product Restrictions').

Type:
Antigen: CD54 (ICAM-1)
Clonality: Monoclonal
Clone: YN1/1.7.4
Conjugation: Unconjugated
Epitope:
Host: Rat
Isotype: IgG2b kappa
Reactivity: Mouse
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