Anti-CD4 Mouse Monoclonal Antibody [clone: RPA-T4] (PE)

Leverantör: STEMCELL Technologies
100-0304 100-0305 100-0306
STMC100-0304EA 781 SEK
STMC100-0304 STMC100-0305 STMC100-0306
Anti-CD4 Mouse Monoclonal Antibody [clone: RPA-T4] (PE)
Antikroppar
Mouse monoclonal IgG1, antibody against human, chimpanzee CD4, PE-conjugated.

  • T cells

The RPA-T4 antibody reacts with CD4, an ~59 kDa single-chain type 1 transmembrane glycoprotein and member of the immunoglobulin (Ig) superfamily; CD4 contains four extracellular Ig-like domains (D1 - D4). The epitope for RPA-T4 has been localized to the D1 domain of the protein, which has a structure resembling an Ig variable domain. CD4 is expressed at relatively high levels by most thymocytes and a subpopulation of T cells (T helper cells), and at lower levels by peripheral blood monocytes and macrophages. CD4 binds to a nonpolymorphic region of MHC II and acts as a co-receptor to the T cell receptor (TCR) in MHC II-restricted antigen recognition by enhancing the affinity of the association between the TCR and MHC II-antigen complex. CD4 also functions to amplify signals from the TCR to the cytoplasm through the interaction of its intracellular domain with cytoplasmic tyrosine kinases, such as Lck. Moreover, CD4 is a receptor for the human immunodeficiency virus (HIV). Binding of the RPA-T4 antibody blocks HIV binding and mixed lymphocyte reaction (MLR), and inhibits the activation of CD4+ T cells in vitro by interfering with the association of CD4 and HLA-DR. It also partially blocks the binding of antibody clone SK3. The epitope of the RPA-T4 antibody is reportedly sensitive to formaldehyde fixation.

Observera: Product restrictions: (i) Customer shall not make products or any portion of them in any way, shape or form, including as a component of another product available for the purpose of further resale or alter or remove the Product label and the Supplier’s mark of origin without express written permission of Supplier and (ii) Customer is familiar with Supplier’s restrictions on the use of the products and shall use the products in compliance with such restrictions and the applicable Supplier Product Information sheet (collectively, the 'Product Restrictions').

Type:
Antigen: CD4
Clonality: Monoclonal
Clone: RPA-T4
Conjugation: PE
Epitope:
Host: Mouse
Isotype:
Reactivity: Chimpanzee, Human
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