Anti-CD8a Mouse Monoclonal Antibody [clone: SK1] (CF®514)

Leverantör: Biotium

P009-514-125 P009-514-500
P009-514-125EA 1550 SEK
P009-514-125 P009-514-500
Anti-CD8a Mouse Monoclonal Antibody [clone: SK1] (CF®514)
Antikroppar
CD8a (clone SK1) is a validated mouse monoclonal antibody that recognises CD8a, a transmembrane glycoprotein and co-receptor found in T cells. This antibody derived from the CD8 alpha chain. The antibody is available conjugated to CF® Dyes and Astral™ tandem dyes. They are supplied in PBS, 0,1% BSA, 0,05% azide.

  • Cell/tissue expression: Lymphocytes, T-cells
  • Tumor expression: Leukemia/lymphoma
  • SwissProt: P01732
  • Unigene: 85258
  • Positive control: Human peripheral blood mononuclear cells (PBMCs), CCRF-CEM or HL-60
  • Ex/Em: 516/549 nm

CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha/beta) or as a homodimer (CD8 alpha/alpha). A majority of thymocytes and a subpopulation of mature T cells and NK cells express CD8a. CD8 binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells.

For mature T-cells, CD4 and CD8 are mutually exclusive, so anti-CD8, generally used in conjunction with anti-CD4. It is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral T-cell lymphomas are CD4 /CD8-. Anaplastic large cell lymphoma is usually CD4 and CD8-, and in T-lymphoblastic lymphoma/leukemia, CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen.

Type: Primary
Antigen: CD8a
Clonality: Monoclonal
Clone: SK1
Conjugation:CF®514
Epitope:
Host: Mouse
Isotype: IgG1, kappa
Reactivity: Human
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