BQCA (synthetic) ≥97%
Leverantör: ENZO LIFE SCIENCES AG
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Varning
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Synonyms:
1-(4-Methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, Benzyl quinolone carboxylic acid.
Acetylcholine receptor activator.
Highly selective allosteric potentiator of the M₁ muscarinic acetylcholine receptor (mAChR). Reduces the concentration of ACh required to activate M₁ up to 129-fold and displays no potentiation, agonism or antagonism activity at other mAChRs at concentrations up to 100 µM. Reverses scopolamine-induced memory deficits and increases blood flow to the cerebral cortex in mouse models.
M₁ activators slow the progression of Alzheimer's disease. Induces β-arrestin recruitment to M₁. At 100 µM, it activated M₁ in the absence of ACh to ca. 50% maximal response. At 10 µM, it reduced the concentration of ACh required to displace radioligand by 45-fold. In vivo experiments were carried out in mice at 15 or 20 mg/kg. The compound is cell permeable, brain penetrant and orally active.
Soluble in DMSO (10 mg/ml).
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Formel:
C₁₈H₁₅NO₄ MW: 309,3 g/mol |
MDL Number:
MFCD01315710 CAS nummer: 338747-41-4 |
Specifikation testresultat
| Source | Synthetic |
| Purity | ≥97% (HPLC) |
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