BAY 41-2272
Leverantör: ENZO LIFE SCIENCES AG
Synonyms:
5-Cyclopropyl-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-amine
Guanylyl cyclase activator
NO-independent activator of soluble guanylyl cyclase (sGC). Activates both isoforms alpha1beta1 and alpha1beta2 of sGC. While the related compound YC-1 (Prod. No. ALX-420-025) also acts as a non-specific phosphodiesterase inhibitor, BAY 41-2272 has no effect on phosphodiesterases. Stimulation of sGC is not blocked by high concentrations of NO scavengers (e.g. PTIO, Prod. No. ALX-430-007) and the combination of BAY 41-2272 with the NO donor DEA NONOate (Prod. No. ALX-430-034) potentiates the activation of sGC. Although BAY 41-2272 alone is not as strong a stimulator of sGC as NO, concentrations as low as 10-100nM stimulate sGC to a level that would be expected to cause biologically important increases in cGMP. ODQ (Prod. No. ALX-270-034), a potent and selective inhibitor of sGC, completely inhibited the effect of BAY 41-2272. The activity of BAY 41-2272 is described in selected literature references.
Formel:
C₂₀H₁₇FN₆ MW: 360,3876 g/mol |
MDL Number:
MFCD06411391 CAS nummer: 256376-24-6 |
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