[-]-Deguelin ≥95%
Leverantör: ENZO LIFE SCIENCES AG
Synonyms:
Deguelin, (7aS,13aS)-9,10-Dimethoxy-3,3-dimethyl-13,13a-dihydro-3H-pyrano[2,3-c:6,5-f']dichromen-7(7aH)-one, (7aS,13aS)-13,13a-Dihydro-9,10-dimethoxy-3,3-dimethyl-3H-bis[1]benzopyrano[3,4-b:6′,5′-e]pyran-7(7aH)-one
COX-2 inhibitor
Inhibitor of Akt (protein kinase B; PKB) in an in vitro lung carcinogenesis progression model. Inhibits cell proliferation - cells accumulate in the G2-M phase of the cell cycle. Premalignant and malignant human brochial epithelial cells are highly sensitive to deguelin compared to normal cells. Induces apoptosis. Exhibits a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. Inhibits cyclooxygenase-2 (COX-2) expression.
Formel:
C₂₃H₂₂O₆ MW: 394,42 g/mol Storage Temperature: Kylskåp |
MDL Number:
MFCD01740600 CAS nummer: 522-17-8 |
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