Y-27632 dihydrochloride ≥98%
Leverantör: ENZO LIFE SCIENCES AG
Synonyms:
Y-27632 2HCl, (R)-(+)-trans-4-(1-Aminoethyl)-N-(4-Pyridyl)cyclohexanecarboxamide dihydrochloride, Rock inhibitor y-27632, trans-4-((R)-1-Aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide dihydrochloride
ROCK inhibitor
Highly potent, cell permeable, selective and ATP competitive inhibitor of ROCK1 and ROCK2 (IC50=800nM). Acts as a potent inhibitor of agonist-induced Ca²⁺ sensitization of myosin phosphorylation and smooth muscle contractions. Blocks cell spreading and suppresses RhoA-induced formation of stress fibers in hepatic stellate cells. Significantly reduces the increase of inflammatory cytokines after reperfusion, preventing the development of acute renal failure. Produces cardioprotective effects. Suppresses tumor cell invasion. Inhibits superoxide production, intrahepatic metastasis of human hepatocellular carcinoma as well as high K+-induced contractions in vascular smooth muscle. Mimics effects of β-agonists on human cells. Has antinociceptive effect.
Formel:
C₁₄H₂₁N₃O·2HCl MW: 320,26 g/mol |
MDL Number:
MFCD03490488 CAS nummer: 129830-38-2 | 146986-50-7 (free base) |
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