XAV939 ≥98%

Leverantör: ENZO LIFE SCIENCES AG

Synonyms: 2-(4-(Trifluoromethyl)phenyl)-3,5,7,8-tetrahydro-4H-thiopyrano[4,3-d]pyrimidin-4-one, XAV-939

BMLWN1000005 BMLWN1000025
ENZOBMLWN1000005EA 735 SEK
ENZOBMLWN1000005 ENZOBMLWN1000025
XAV939 ≥98%
XAV939

PARP5a inhibitor


Potent inhibitor of Tankyrase 1 (IC50=11nM) and Tankyrase 2 (IC50=4nM). Inhibition of tankyrase promotes stabilization of axin resulting in β-catenin degradation and Wnt signalling disruption. Inhibits proliferation of the μ-catenin-dependent colon carcinoma cell line DLD-1. Promotes cardiomyogenic development in mesoderm progenitor cells.

Formel: C₁₄H₁₁F₃N₂OS
MW: 312,3102 g/mol
MDL Number: MFCD16879017
CAS nummer: 284028-89-3
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