Apicidin ≥99% (by HPLC, TLC)

Leverantör: ENZO LIFE SCIENCES AG

Synonyms: cyclo-[L-(2-Amino-8-oxodecanoyl)-L-(N-methoxy-tryptophan)-L-isoleucyl-D-pipecolinyl]

BMLGR3400001 BMLGR3400005
ENZOBMLGR3400001EA 965 SEK
ENZOBMLGR3400001 ENZOBMLGR3400005
Apicidin ≥99% (by HPLC, TLC)
Apicidin

HDAC inhibitor


Potent inhibitor of histone deacetylase (HDAC). Inhibits proliferation. Induces cell cycle arrest at the G1 phase. At 100nM it induces a long lasting hyperacetylation of histone H4 while that induced by trichostatin is transient. Stimulates apoptosis. Apoptosis is induced via induction of Fas/Fas ligand. Displays potent antiangiogenic effects and dramatically decreases HIF-1α protein levels and transcriptional activity in human and mouse tumor cell lines. Antiprotozoal.

Formel: C₃₄H₄₉N₅O₆
MW: 623,8 g/mol
CAS nummer: 183506-66-3

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