Gambogic amide ≥98%
Leverantör: ENZO LIFE SCIENCES AG
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Fara
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BMLN1590001
BMLN1590005
ENZOBMLN1590001EA
1500
SEK
ENZOBMLN1590001
ENZOBMLN1590005
Gambogic amide ≥98%
Gambogic amide
TrkA ligand
A novel small molecule NGF mimic discovered using a cell-based chemical genetic screen for TrkA agonists. Gambogic amide selectively binds to TrkA, triggers its tyrosine phosphorylation, elicits PI3-kinase/Akt and MAPK activation, provokes neurite outgrowth in PC12 cells and prevents neuronal cell death. EC50 for antiapoptotic activity is 5nM.
Soluble in DMSO (20 mg/ml) or ethanol (20 mg/ml).
Formel:
C₃₈H₄₅NO₇ Smältpunkt: 74…76 °C Storage Temperature: Omgivande |
CAS nummer:
286935-60-2 |
Specifikation testresultat
Purity | ≥98% (TLC) |
Appearance | Yellow-orange solid |
Melting Point | 74 - 76°C |
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