PP1 ≥98%

Leverantör: ENZO LIFE SCIENCES AG

Synonyms: 1-(tert-Butyl)-3-(p-tolyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

BMLEI2750001 BMLEI2750005
ENZOBMLEI2750001EA 1225 SEK
ENZOBMLEI2750001 ENZOBMLEI2750005
PP1 ≥98%
PP1

Src kinase inhibitor


A highly potent and selective inhibitor of Src family tyrosine kinases, IC50=5 nM for p56lck; p59fynT=6 nM; p60src=170 nM. Inhibition of Src family kinases by PP1 has been shown to: prevent a-thrombin-stimulated Akt phosphorylation, delay PAF-mediated STAT3 phosphorylation, block Zn2+-induced Ras activation, block adhesion-dependent tyrosine phosphorylation of p105HEF1 5, and inhibit HLA-DR-induced tyrosine phosphorylation without affecting the activation of ERK1/2.

Formel: C₁₆H₁₉N₅
MW: 281,4 g/mol
MDL Number: MFCD01076570
CAS nummer: 172889-26-8
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