BAY 11-7085 ≥99%
Leverantör: ENZO LIFE SCIENCES AG
Synonyms:
(E)-3-(4-tert-Butylphenylsulphonyl)acrylonitrile, (E)-3-((4-(tert-Butyl)phenyl)sulphonyl)acrylonitrile
NF-kappaB inhibitor
An irreversible inhibitor of cytokine-inducible IkappaBalpha phosphorylation (IC50=10 µM). In intact HUVECs it inhibits TNFalpha-induced phosphorylation and degradation of IkappaBalpha without affecting constitutive phosphorylation. Inhibition of IkappaBalpha phosphorylation and degradation results in the inactivation of NF-kappaB and NF-kappaB-dependent expression of endothelial-leukocyte adhesion molecules, E-selectin, VCAM-1 and ICAM-1. BAY 11-7085 displayed potent anti-inflammatory activity in the rat carrageenan paw edema assay and adjuvant arthritis model.
Formel:
C₁₃H₁₅NO₂S MW: 249,328 g/mol |
MDL Number:
MFCD01862602 CAS nummer: 196309-76-9 |
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