BAY 11-7085 ≥99%

Leverantör: ENZO LIFE SCIENCES AG

Synonyms: (E)-3-(4-tert-Butylphenylsulphonyl)acrylonitrile, (E)-3-((4-(tert-Butyl)phenyl)sulphonyl)acrylonitrile

BMLEI2790010 BMLEI2790050
ENZOBMLEI2790010EA 1225 SEK
ENZOBMLEI2790010 ENZOBMLEI2790050
BAY 11-7085 ≥99%
BAY 11-7085

NF-kappaB inhibitor


An irreversible inhibitor of cytokine-inducible IkappaBalpha phosphorylation (IC50=10 µM). In intact HUVECs it inhibits TNFalpha-induced phosphorylation and degradation of IkappaBalpha without affecting constitutive phosphorylation. Inhibition of IkappaBalpha phosphorylation and degradation results in the inactivation of NF-kappaB and NF-kappaB-dependent expression of endothelial-leukocyte adhesion molecules, E-selectin, VCAM-1 and ICAM-1. BAY 11-7085 displayed potent anti-inflammatory activity in the rat carrageenan paw edema assay and adjuvant arthritis model.

Formel: C₁₃H₁₅NO₂S
MW: 249,328 g/mol
MDL Number: MFCD01862602
CAS nummer: 196309-76-9
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