2-Morpholino-8-phenylchromone ≥98%

Leverantör: ENZO LIFE SCIENCES AG

Synonyms: LY294002, LY 294002, 2-Morpholino-8-phenyl-4H-chromen-4-one, 2-Morpholino-8-phenyl-4-oxo-4H-1-benzopyran

BMLST4200005 BMLST4200025
ENZOBMLST4200005EA 1500 SEK
ENZOBMLST4200005 ENZOBMLST4200025
2-Morpholino-8-phenylchromone ≥98%
2-Morpholino-8-phenylchromone

PI3 kinase inhibitor


Potent, cell permeable, inhibitor of PI(3)K (phosphoinositide 3-kinase) that acts on the ATP-binding site of the enzyme. Displays an IC50 of 1.4 µM and inhibits all isoforms equally in in vitro assays using purified PI 3-kinase. (p110alpha IC50=0.63µM)Inhibits Pim-1 kinase with IC50=4.0µM.Other kinases such as PKC, PKA, MAP kinase, S6 kinase, EGF receptor tyrosine kinase, c-src kinase, PI 4-kinase, diacylglycerol kinase or rabbit kidney ATPase are not inhibited at 50µM. Induces apoptosis in many cell types by blocking the PI3-K/Akt anti-apoptotic pathway. Useful tool for identifying cellular events which are regulated by the PI3-K/Akt axis. Sensitizes tumor cells to drug-induced apoptosis independent of its PI3K inhibitory activity. For a negative control see LY-303,511 (Prod. No. ALX-270-410).

Formel: C₁₉H₁₇NO₃
MW: 307,35 g/mol
MDL Number: MFCD00270881
CAS nummer: 154447-36-6
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