2-Morpholino-8-phenylchromone ≥98%
Leverantör: ENZO LIFE SCIENCES AG
Synonyms:
LY294002, LY 294002, 2-Morpholino-8-phenyl-4H-chromen-4-one, 2-Morpholino-8-phenyl-4-oxo-4H-1-benzopyran
PI3 kinase inhibitor
Potent, cell permeable, inhibitor of PI(3)K (phosphoinositide 3-kinase) that acts on the ATP-binding site of the enzyme. Displays an IC50 of 1.4 µM and inhibits all isoforms equally in in vitro assays using purified PI 3-kinase. (p110alpha IC50=0.63µM)Inhibits Pim-1 kinase with IC50=4.0µM.Other kinases such as PKC, PKA, MAP kinase, S6 kinase, EGF receptor tyrosine kinase, c-src kinase, PI 4-kinase, diacylglycerol kinase or rabbit kidney ATPase are not inhibited at 50µM. Induces apoptosis in many cell types by blocking the PI3-K/Akt anti-apoptotic pathway. Useful tool for identifying cellular events which are regulated by the PI3-K/Akt axis. Sensitizes tumor cells to drug-induced apoptosis independent of its PI3K inhibitory activity. For a negative control see LY-303,511 (Prod. No. ALX-270-410).
Formel:
C₁₉H₁₇NO₃ MW: 307,35 g/mol |
MDL Number:
MFCD00270881 CAS nummer: 154447-36-6 |
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