Microcystis aeruginosa [D-Asp3]microcystin-LR

Leverantör: ENZO LIFE SCIENCES AG

ALX350173C025 ALX350173C100
ENZOALX350173C025EA 3075 SEK
ENZOALX350173C025 ENZOALX350173C100
Microcystis aeruginosa [D-Asp3]microcystin-LR
Proteiner

Microcystins are a group of cyclic heptapeptide hepatotoxins produced by a number of cyanobacterial genera. The most notable of which, and namesake, is the widespread genus Microcystis. Structurally, all microcystins consist of the generalized structure cyclo(-D-Ala1-X2-D-MeAsp3-Y4-Adda5-D-Glu6-Mdha7-). X and Y are variable L-amino acids, D-MeAsp is D-erythro-β-methylaspartic acid and Mdha is N-methyldehydroalanine. Adda is the cyanobacteria unique C20 β-amino acid 3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoic acid. Substitutions of the variable L-amino acids at positions 2 and 4 give rise to at least 21 known primary microcystin analogs and alterations in the other constituent amino acids result in more than 90 reported mycrocystins to date.


Isolated from Microcystis aeruginosa. Microcystin containing a leucine (L) in position 2 and arginine (R) in position 4. Additionally, the D-MeAsp at position 3 is demethylated to Asp. Hepatotoxic.

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