Anti-TYMS Mouse Monoclonal Antibody (CF568) [clone: TS106 TMS715]

Leverantör: Biotium

BNC680716-500 BNC680716-100
BNC680716-500EA 6150 SEK
BNC680716-500 BNC680716-100
Anti-TYMS Mouse Monoclonal Antibody (CF568) [clone: TS106 TMS715]
Antikroppar
This antibody recognizes a protein of 36 kDa, identified as Thymidylate Synthase (TS) (EC 2.1.1.45). TS converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.

Type: Primary
Antigen: TYMS
Clonality: Monoclonal
Clone: TS106 TMS715
Conjugation: CF568
Epitope:
Host: Mouse
Isotype: IgGs
Reactivity: Human
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