Antibiotics & Antimycotics
Antibiotics and Antimycotics
Antibiotics and Antimycotics are a type of antimicrobial drug used in the treatment and prevention of bacterial infections. They may either kill or inhibit the growth of microorganisms.
In science those substances are mostly used in cell culture. They are used to select for a specific type of cells. Either when cultivating mammal cells to exclude bacteria or e.g. to select for genetically modified cells which carry a resistance gene for selection on them.
PanReac AppliChem antibiotics and antimycotics prove to be used from small assays to bigger incubators. On this page you can find a selection of our finest most common used products from this product range.
Also here it is about trust and reproducibility for all your experiments and growing in cell culture or microbiology.
List of selected antibiotics:
| Product No. | Description | Target organism |
Mode of action |
Recommended working concentration |
Stock solution |
| Amphotericin B |
fungi, yeast |
binds to sterols with planar structure and impairs with membrane permeability |
0.25 µg/ml |
30-40 mg/ml in DMSO |
|
| Blasticidin S hydrochloride |
Prokaryotes, Eukaryotes |
inhibits protein biosynthesis by preventing the formation of the peptide bond |
3-100 µg/ml |
50 mg/ml in H2O or buffer store at +4°C - -20°C |
|
| Carbenicillin disodium salt |
gram negative germs, enterococci |
inhibits cell wall synthesis (transpeptidase) in growing bacteria |
20-60 µg/ml |
50 mg/ml in H2O/MeOH 1:1 store at -20°C |
|
| Cycloheximide (Actidion) |
fungi, eukaryotes |
binds to 80 S ribosome in eukaryotic cells; inhibits formation of peptide bond |
10 µg/ml |
10 mg/ml |
|
| Gentamycin sulfate |
gram positive/ negative germs |
inhibits protein synthesis by binding to the L6 protein of the 50 S ribosomal subunit |
15-50 µg/ml |
10-20 mg/ml in water, formamide |
|
| Hygromycin B - Solution |
10-400 µg/ml |
ca. 41 mg/ml in H2O; store at -20°C |
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| Kanamycin sulfate & Kanamycin Sulfate (Ph. Eur., BP) pure, pharma rade |
gram positive/ |
inhibits protein synthesis (translocation) |
10-100 µg/ml |
10 mg/ml in H2O |
|
| Polymyxin B sulfate |
gram negative bacteria - non- proliferating germs too |
interaction with phospholipid components of the bact. cell membrane; changes permeability of the membrane and causes efflux of essential plasma compounds |
50 µg/ml |
25 mg/ml H2O, MeOH |
|
| Vancomycin hydrochloride |
bacteriostatic and bacterizide against gram positive cocci and bacteria |
amphoteric glyopeptide antibiotic; binds to bacterial cell wall precursors (peptidoglycans) |
1-25 µg/ml |
soluble in water ›100 mg/ml |