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Lead standard solution (0.1% Pb) Reag. Ph. Eur. 5001700

Artikel nummer : (88087.180)

Leverantör: VWR Chemicals

Beskrivning: Lead standard solution (0.1% Pb) Reag. Ph. Eur. 5001700

UOM: 1 * 100 mL

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N/A Each

Bly(II)nitrat ≥99%

Leverantör: Thermo Fisher Scientific

Beskrivning: Bly(II)nitrat ≥99%

Säkerhetsdatablad Certifikat

Bly(II)nitrat ≥99.0% ACS, Fluka™

Leverantör: Honeywell Chemicals

Beskrivning: Bly(II)nitrat ≥99.0% ACS, Fluka™

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Anti-SNCA Rat Monoclonal Antibody

Leverantör: ENZO LIFE SCIENCES

Beskrivning: Synuclein was originally identified in Torpedo californica as a small neuroprotein that localized to the nuclear envelope of neurons and to presynaptic nerve termini. The human homolog was initially termed NACP, a precursor protein to NAC (Non-Ab Component), because of its prevalence in amyloid plaques in Alzheimer’s patients. Later, NACP was recognized as being alpha-Synuclein (alpha-SYN), a 14kDa protein, belonging to the synuclein family of phosphoproteins that also includes: betalpha-SYNuclein, gammalpha-SYNuclein, and synoretin.
alpha-SYN is recognized as a key component in the development and diagnosis of neurodegenerative synucleinopathic diseases (NSDs), such as Alzheimer’s and Parkinson’s disease. In the past five years, several genetic and post-translational modifications to alpha-SYN have been elucidated that have been linked to its collaboration in the formation of the classical Lewy bodies (LBs) or Lewy neurites that are associated with neurodegeneration. A study that shed more light on the neurogenesis of autorecessive synucleinopathies (ARSs) was the finding that alpha-SYN accumulation can occur due to mutations in the E3 ubiquitin ligase.
ARSs only account for a small percentage of NSD. Thus the illustration that alpha-SYN has a high susceptibility to tyrosine nitration may be the key component in understanding the formation of LBs. Due to the chemical structure of alpha-SYN, tyrosine nitration readily leads to the formation of oligomers via covalent O,O’-dityrosine bonds (cross-linking). Nitrosylated, wild-type, alpha-SYN products thus form SDS-insoluble, heat-stable aggregates in vitro that may account for alpha-SYN inclusions in all forms of NSDs.

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