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Artikel nummer : (BOSSBS-3048R-CY7)
Leverantör: Bioss
Beskrivning: Beta Arrestin 1 is a member of a family of proteins that are widely expressed but especially abundant in the central nervous system. Serving as an adaptor or scaffold molecule, beta Arrestin 1 is essential for mitogenic signaling. It mediates agonist dependent desensitization and internalization of G protein coupled receptors (GPCRs, e.g., beta 2 adrenergic receptor). After binding to their ligand and interacting with heterotrimeric G proteins, GPCRs are phosphorylated by G protein receptor kinases (GRKs) on serine residues. Beta Arrestin 1 has important roles in the cytoplasm and at the plasma membrane in the desensitization and internalization of G protein coupled receptors (GPCRs) and is increasingly appreciated to play an important role in the endocytosis and signaling of GPCRs. Beta Arrestin 1 in the cytosol is phosphorylated by ERK1 and 2 on serine 412 in a negative feedback mechanism and binds to the phosphorylated receptors at the plasma membrane. Serine 412 is then dephosphorylated and the GPCRs are internalized, leading to activation of the Ras, Raf, ERK1 and 2 signaling pathway.
UOM: 1 * 100 µl


Artikel nummer : (BOSSBS-3048R-FITC)
Leverantör: Bioss
Beskrivning: Beta Arrestin 1 is a member of a family of proteins that are widely expressed but especially abundant in the central nervous system. Serving as an adaptor or scaffold molecule, beta Arrestin 1 is essential for mitogenic signaling. It mediates agonist dependent desensitization and internalization of G protein coupled receptors (GPCRs, e.g., beta 2 adrenergic receptor). After binding to their ligand and interacting with heterotrimeric G proteins, GPCRs are phosphorylated by G protein receptor kinases (GRKs) on serine residues. Beta Arrestin 1 has important roles in the cytoplasm and at the plasma membrane in the desensitization and internalization of G protein coupled receptors (GPCRs) and is increasingly appreciated to play an important role in the endocytosis and signaling of GPCRs. Beta Arrestin 1 in the cytosol is phosphorylated by ERK1 and 2 on serine 412 in a negative feedback mechanism and binds to the phosphorylated receptors at the plasma membrane. Serine 412 is then dephosphorylated and the GPCRs are internalized, leading to activation of the Ras, Raf, ERK1 and 2 signaling pathway.
UOM: 1 * 100 µl


Artikel nummer : (BOSSBS-5141R)
Leverantör: Bioss
Beskrivning: Matrin 3 (MATR 3) is an internal nuclear matrix protein that may play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer MATR 3 may play a role in nuclear retention of defective RNAs. MATR3 forms part of complex consisting of SFPQ, NONO and MATR3.The protein contains 1 matrin type zinc finger and 2 RRM (RNA recognition motif) domains. Two transcript variants encoding the same protein have been identified for this gene.
UOM: 1 * 100 µl


Leverantör: JULABO GMBH
Beskrivning: The powerful and robust CORIO™ laboratory circulators provide the exact temperature, absolute precision, and a wide working temperature range. The CORIO™ CP model is an advanced unit with professional technology for demanding applications and can be used for temperature control of internal or external applications due to the powerful and infinitely adjustable pressure pump. The jet nozzle allows continuous adjustment of the pump stream in the system. These heating circulators are optimised for external temperature applications in combination with jacketed reactors, distillation apparatus, mini-plant applications, photometers, refractometers and can also be used for internal temperature applications of samples and small objects.

Artikel nummer : (BOSSBS-6501R)
Leverantör: Bioss
Beskrivning: RAB proteins, such as RAB25, are members of the RASsuperfamily of small GTPases that are involved in membranetrafficking. Members of the RAB11 subfamily, including RAB25,control the return of internalized membrane-associated moieties tothe cell surface
UOM: 1 * 100 µl


Artikel nummer : (BOSSBS-2200R-HRP)
Leverantör: Bioss
Beskrivning: Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.
UOM: 1 * 100 µl


Artikel nummer : (BOSSBS-5038R-CY5.5)
Leverantör: Bioss
Beskrivning: Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.
UOM: 1 * 100 µl


Artikel nummer : (BOSSBS-4892R-A488)
Leverantör: Bioss
Beskrivning: Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.
UOM: 1 * 100 µl


Artikel nummer : (BOSSBS-6071R-CY5)
Leverantör: Bioss
Beskrivning: Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor.
UOM: 1 * 100 µl


Leverantör: MULTIROIR
Beskrivning: These airtight boxes are designed to withstand the harshest conditions, both indoors and outdoors. When tightly closed, the boxes become completely sealed, effectively preventing moisture and dust from reaching the contents inside.

Artikel nummer : (BOSSBS-13537R-A750)
Leverantör: Bioss
Beskrivning: Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, ADRBK1/GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses.
UOM: 1 * 100 µl


Artikel nummer : (BOSSBS-13537R-A647)
Leverantör: Bioss
Beskrivning: Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, ADRBK1/GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses.
UOM: 1 * 100 µl


Artikel nummer : (BOSSBS-13537R-A488)
Leverantör: Bioss
Beskrivning: Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, ADRBK1/GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses.
UOM: 1 * 100 µl


Artikel nummer : (BOSSBS-13537R-A350)
Leverantör: Bioss
Beskrivning: Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, ADRBK1/GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses.
UOM: 1 * 100 µl


Artikel nummer : (BOSSBS-6071R-FITC)
Leverantör: Bioss
Beskrivning: Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor.
UOM: 1 * 100 µl


Artikel nummer : (732-2541)
Leverantör: VWR Collection
Beskrivning: The VWR® PCR Workstation is a PCR enclosure for PCR sample preparation and other sensitive protocols. It offers dual decontamination action by UV inactivation of airborne and surface-bound contaminants and, therefore, represents an ideal environment for PCR set up. Stainless steel housing, front and side panels made of 8 mm Makrolon® protects from UV irradiation.
UOM: 1 * 1 Items


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Lager för denna produkt är begränsat, men kan vara tillgänglig i ett lager nära dig. Se till att du är inloggad på hemsidan så att tillgängligt lager kan visas. Om call fortfarande visas och du behöver hjälp, ring oss på 08-621 34 20.
Lager för denna produkt är begränsat, men kan vara tillgänglig i ett lager nära dig. Se till att du är inloggad på hemsidan så att tillgängligt lager kan visas. Om call fortfarande visas och du behöver hjälp, ring oss på 08-621 34 20.
VWR International AB säljer bara etanol till skattebefriade kunder. Denna produkt ä reglerad enligt svensk lagstiftning. Om ytterligare information krävs av dig kommer du att kontaktas via e-post.
VWR International AB säljer bara etanol till skattebefriade kunder.
Denna produkt ä reglerad enligt svensk lagstiftning. Om ytterligare information krävs av dig kommer du att kontaktas via email.
Produkten har blockerats av din organisation. Vänligen kontakta din inköpsavdelning för mer information.
Lösenordet och säkerhetsfrågan associerade med ditt Kundnummer har gått ut. Vänligen ändra ditt lösenord och din säkerhetsfråga.
Denna produkt är inte längre tillgänglig. Alternativ kan vara tillgängliga genom att söka med VWR art.nr ovan. Om du behöver ytterligare hjälp, ring VWR Kundservice på 08-621 34 20.
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