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(R)-Baclofen ≥95.0% (by HPLC, titration analysis)

Leverantör: TCI EUROPE

Beskrivning: (R)-Baclofen ≥95.0% (by HPLC, titration analysis)

R-(+)-Baclofen hydrochloride ≥98%

Artikel nummer : (ENZOALX550074M050)

Leverantör: ENZO LIFE SCIENCES AG

Beskrivning: Selective GABAB receptor agonist.

UOM: 1 * 50 mg

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Pharmaceutical secondary standard, Baclofen, (CRM), Supelco®

Artikel nummer : (PHR1682-1G)

Leverantör: Merck

Beskrivning: Organic Standard, Baclofen

UOM: 1 * 1 g

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Baclofen ≥98.0%

Leverantör: TCI EUROPE

Beskrivning: Baclofen ≥98.0%

Beskrivning: USP Reference Standards are specified for use in conducting official USP–NF tests and assays. USP also provides Reference Standards specified in the Food Chemicals Codex as well as authentic substances—high-quality chemical samples—as a service to analytical, clinical, pharmaceutical and research laboratories. To confirm accuracy and reproducibility, USP Reference Standards are rigorously tested and evaluated by multiple independent laboratories including USP, commercial, regulatory, and academic labs. USP also provide publicly available, official documentary standards for pharmaceutical ingredients in the USP–NF that link directly with our primary reference standards.

Anti-GABBR1 Rabbit Polyclonal Antibody

Artikel nummer : (BOSSBS-0533R)

Leverantör: Bioss

Beskrivning: Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Calcium is required for high affinity binding to GABA. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. Activated by (-)-baclofen, cgp27492 and blocked by phaclofen. Isoform 1E may regulate the formation of functional GABBR1/GABBR2 heterodimers by competing for GABBR2 binding. This could explain the observation that certain small molecule ligands exhibit differential affinity for central versus peripheral sites.

UOM: 1 * 100 µl

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