Aluminon ACS, Sigma-Aldrich®
Leverantör: SIGMA-ALDRICH MICROSCOPY
Synonyms:
Ammonium 5,5'-((3-carboxylato-4-oxocyclohexa-2,5-dien-1-ylidene)methylene)bis(2-hydroxybenzoate), Aurin Tricarboxylic Acid Ammonium Salt
M-Clarity™ quality level = MQ300
Reagent for aluminium. Aurintricarboxylic acid readily polymerises in aqueous solution, forming a stable free radical that inhibits protein-nucleic acid interactions. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. It stimulates tyrosine phosphorylation processes including the Jak2/STAT5 pathway in NB2 lymphoma cells, ErbB4 in neuroblastoma cells, and MAP kinases, Shc proteins, phosphatidylinositide 3-kinase and phospholipase C in PC12 cells. Aurintricarboxylic acid inhibits apoptosis in many cell types. Its neuroprotective effect, perhaps due to its ability to prevent down-regulation of Ca²⁺ impermeable GluR2 receptors or to its ability to inhibit calpain, a Ca²⁺-activated protease that is activated during apoptosis.
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Formel:
C₂₂H₂₃N₃O₉ MW: 473,44 g/mol Smältpunkt: 220,..225 °C (dec., lit.) Storage Temperature: Room Temperature |
MDL Number:
MFCD00040925 CAS nummer: 569-58-4 EINECS: 209-319-1 |
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Specifikation testresultat
| Appearance (Colour) | Red to Very Dark Red and Red-Brown and Brown-Red |
| Appearance (Form) | Powder or Crystals |
| Infrared spectrum | Conforms to Structure |
| Insoluble matter, c = 1%, Water and Dilute NH4OH | ≤0.1% |
| Sensitivity Test, Sensitivty to Aluminum | Pass |
| Residue on ignition (Ash) | ≤0.2% |
| Solubility (Colour) c = 100 mg/ml; Water | Red to Very Dark Red and Red-Brown and Brown-Red |
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