GW5074 ≥98%
Leverantör: ENZO LIFE SCIENCES AG
Synonyms:
5-Iodo-3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-2-indolinone, 3-(3,5-dibromo-4-hydroxybenzylidene)-5-iodoindolin-2-one, GW 5074
Potent and selective cell permeable inhibitor of cRAF1 kinase (IC50 = 9 nM) with 100-fold selectivity over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. A useful tool for assessing the involvement of the Ras/Raf-1/ERK pathway in various signaling pathways. Displays neuroprotective effects in vivo through a MEK-ERK and Akt-independent mechanism.
- Raf inhibitor
Yellow to orange solid.
Soluble in DMSO (>25 mg/ml).
Formel:
C₁₅H₈Br₂INO₂ MW: 520,94 g/mol Storage Temperature: Frys |
MDL Number:
MFCD09971042 CAS nummer: 220904-83-6 |
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