IQ-1 ≥98%
Synonyms:
2-((4-Acetylphenyl)diazenyl)-2-(3,3-dimethyl-3,4-dihydroisoquinolin-1(2H)-ylidene)acetamide, Wnt Pathway Activator III, IQ 1, 2-(4-Acetylphenylazo)-2-(3,3-dimethyl-3,4-dihydro-2H-isoquinolin-1-ylidene)-acetamide
Disrupts Wnt signaling
IQ-1 in conjunction with Wnt3a has been shown to be sufficient to maintain murine embryonic stem cell proliferation in the absence of serum. Binds to the PR72/PR130 subunit of protein phosphatase PP2A preventing β-catenin from switching co-activator usage from CBP to p300 leading to an increase in β-catenin/CBP-driven transcription at the expense of β-catenin/p300-driven transcription. Upregulates expression of Oct4 and Sox2 transcription factors.
Formel:
C₂₁H₂₂N₄O₂ MW: 362,43 g/mol |
MDL Number:
MFCD00354369 CAS nummer: 331001-62-8 |
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