K-252a ≥98%

Leverantör: ENZO LIFE SCIENCES AG

Synonyms: Methyl-6-hydroxy-5-methyl-13-oxo-5,6,7,8,14,15-hexahydro-13h-5,8-epoxy-4b,8a,14-triazadibenzo[b,h]cycloocta[1,2,3,4-jkl]cyclopenta[e]-as-indacene-6-carboxylate

BMLEI1520100 BMLEI1521000
ENZOBMLEI1520100EA 1750 SEK
ENZOBMLEI1520100 ENZOBMLEI1521000
K-252a ≥98%
K-252a

Protein kinase inhibitor


Alkaloid isolated from soil fungi. General, cell permeable protein kinase inhibitor. Acts by binding to the ATP binding domain of the kinase. Potent inhibitor of Ca2+/calmodulin kinase II. Inhibits myosin light chain kinase, cAMP-dependent protein kinase (PKA), protein kinase C (PKC) (Ki=25nM), trk tyrosine kinase family members (gp140trk; IC50 =3nM) and cGMP-dependent protein kinase (PKG). Binds with high affinity to neuroblastoma membrane (2.7nM), promoting survival of primary neuronal cultures (75nM) and induction of neurite outgrowth in SH-SY5Y neuroblastoma cells along with phosphorylation of pp125 focal adhesion protein tyrosine kinase. Induces apoptosis.

Formel: C₂₇H₂₁N₃O₅
MW: 467,481 g/mol
MDL Number: MFCD00161522
CAS nummer: 97161-97-2
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