1,9-Pyrazoloanthrone ≥98%

Leverantör: ENZO LIFE SCIENCES AG

Synonyms: JNK Inhibitor II, Anthra[1,9-cd]pyrazol-6(2H)-one, Dibenzo[cd,g]indazol-6(2H)-one, SP600125, SP 600125

BMLEI3050010 BMLEI3050050
ENZOBMLEI3050010EA 945 SEK
ENZOBMLEI3050010 ENZOBMLEI3050050
1,9-Pyrazoloanthrone ≥98%
1,9-Pyrazoloanthrone

Potent, cell permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC50=40nM for JNK-1 and JNK-2 and 90nM for JNK-3). The inhibition is competitive with respect to ATP. Exhibits over 300-fold greater selectivity for JNK as compared to ERK1 and p38. Inhibits the phosphorylation of c-Jun and blocks the expression of IL-2, IFN-γ, TNF-α, and COX-2. Blocks IL-1-induced accumulation of phospho-Jun, induction of c-Jun transcription and anti CD3-induced apoptosis of CD4+ CD8+ thymocytes.


  • Jnk inhibitor


Yellow to brown solid.


Soluble in DMSO or methanol.

Formel: C₁₄H₈N₂O
MW: 220,231 g/mol
Storage Temperature: Omgivande
MDL Number: MFCD00022289
CAS nummer: 129-56-6
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