1,9-Pyrazoloanthrone ≥98%
Leverantör: ENZO LIFE SCIENCES AG
Synonyms:
JNK Inhibitor II, Anthra[1,9-cd]pyrazol-6(2H)-one, Dibenzo[cd,g]indazol-6(2H)-one, SP600125, SP 600125
Potent, cell permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC50=40nM for JNK-1 and JNK-2 and 90nM for JNK-3). The inhibition is competitive with respect to ATP. Exhibits over 300-fold greater selectivity for JNK as compared to ERK1 and p38. Inhibits the phosphorylation of c-Jun and blocks the expression of IL-2, IFN-γ, TNF-α, and COX-2. Blocks IL-1-induced accumulation of phospho-Jun, induction of c-Jun transcription and anti CD3-induced apoptosis of CD4+ CD8+ thymocytes.
- Jnk inhibitor
Yellow to brown solid.
Soluble in DMSO or methanol.
Formel:
C₁₄H₈N₂O MW: 220,231 g/mol Storage Temperature: Omgivande |
MDL Number:
MFCD00022289 CAS nummer: 129-56-6 |
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