Tyrphostin AG 490 ≥98%

Leverantör: ENZO LIFE SCIENCES AG

Synonyms: (E)-N-Benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide, AG490

BMLEI2720010 BMLEI2720050
ENZOBMLEI2720010EA 1225 SEK
ENZOBMLEI2720010 ENZOBMLEI2720050
Tyrphostin AG 490 ≥98%
Tyrphostin AG 490

AG-490 is a potent inhibitor of the JAK-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells, which abundantly express JAK-2, AG-490 dose-dependently inhibited DNA synthesis, blocked cell growth and induced apoptosis. At 5 µM, AG-490 almost completely blocked the growth of all pre-B ALL cells but had no significant effect on the growth of mitogen-stimulated normal B or T cells, B-cell lymphoma or T-cell leukemia cells. AG-490 does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. It blocks interleukin-7-induced JAK kinase activity in T-cells (JAK-1, JAK-3) and the consequent phosphorylation of PI-3 kinase. AG-490 is cell permeable and is a valuable tool for studying the cellular role of JAK kinases in signal transduction.


  • JAK inhibitor


Tan solid.


Soluble in DMSO (30mg/ml), dimethyl formamide (40mg/ml) or 100% ethanol (10mg/ml).

Formel: C₁₇H₁₄N₂O₃
MW: 294,31 g/mol
Storage Temperature: Frys
MDL Number: MFCD00236452
CAS nummer: 133550-30-8
https://digitalassets.avantorsciences.com/adaptivemedia/rendition?id=15c67152b82061a07c498a8402404b363bebc402&vid=81a87aa3472ec4637c5b64ecedd7226190aba598&prid=web&clid=SAPDAM

Order Now

Learn more

About VWR

Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...

Läs mer About VWR