Dexamethasone ≥99%
Leverantör: ENZO LIFE SCIENCES AG
Synonyms:
Dexamethasonum, 9-Fluor-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadien-3,20-dion
Glucocorticoid receptor ligand
Anti-inflammatory glucocorticoid with anti-inflammatory activity. Induces the production of phospholipase A2 inhibitory protein (lipocortin). Inhibits induction of nitric oxide synthase (NOS) (IC50=5nM). Induces apoptosis in eosinophils, but inhibits it in neutrophils. Both effects are blocked by RU-486. Modulates osteogenesis of mesenchymal stem cells. Inhibits constitutive OPG mRNA steady-state levels in a dose- and time-dependent fashion, promoting osteoclast formation. Oral dexamethasone administration induces an increase in insulin resistance in humans. Activates Indoleamine 2,3-dioxygenase (IDO) in plasmacytoid dendritic cells in vivo and thus promotes tryptophan catabolism and thereby suppression of T cells.
Formel:
C₂₂H₂₉FO₅ MW: 392,47 g/mol |
MDL Number:
MFCD00064136 CAS nummer: 50-02-2 |
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