Y-27632 dihydrochloride
Leverantör: Cayman Chemical
Synonyms:
Y-27632 2HCl, (R)-(+)-trans-4-(1-Aminoethyl)-N-(4-Pyridyl)cyclohexanecarboxamide dihydrochloride, Rock inhibitor y-27632, trans-4-((R)-1-Aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide dihydrochloride
Y-27632 is a potent, ATP-competitive inhibitor of ROCKs including p160ROCK (Ki = 140 nm) and ROCK-II (IC50 = 800 nm). It also inhibits PRK2 with an IC50 value of 600 nm.
- Crystalline solid
- Purity ≥98%
- Storage at −20 °C
One-hour treatment with 10 µm Y-27632 blocks apoptosis of dissociated cultured human embryonic stem cells, increasing cloning efficiency by 25% and sustaining survival up to 30 passage.
Formel:
C₁₄H₂₁N₃O·2HCl MW: 320,26 g/mol |
MDL Number:
MFCD03490488 CAS nummer: 129830-38-2 | 146986-50-7 (free base) |
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