5-Fluoro-2'-deoxyuridine (floxuridine) ≥98%, white powder
Leverantör: MP Biomedicals
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Fara
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Synonyms:
5-Fluoro-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione, 5-Fluoro-2'-deoxyuridine, Floxuridine
5-Fluorodeoxyuridine is an antineoplastic agent, which acts as an anti-metabolite. When administrated by rapid injection it acts as flurouracil, but when infused slowly, usually intra-arterially, it is converted to active F-dUMP, which leads to enhanced inhibition of DNA synthesis. It inhibits DNA synthesis by blocking thymidylic acid synthetase.
- Extinction Coefficient (E1%): EmM = 8.91 (0.1 M phosphate buffer, pH 6.0) (Lit.)
- Optical Rotation: +37 ° (10 mg/mL in water at 25 °C) (Lit.)
- pKa:7.6 (Lit.)
5-Fluorodeoxyuridine can be used to target thymidylate synthetase in cancer chemotherapy. Experimental anticancer agent shown to have activity against a variety of malignant neoplasms, including mouse mammary tumors and colorectal carcinomas.
Antineoplastic drug that acts as a potent inhibitor of thymidylate synthetase. Resistance to FUdR can develop in cancer cell cultures, among other means, by low-level Mycoplasma infection.
Soluble in water (clear, colourless solution); DMF.
Observera: Research Use Only (RUO).
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Formel:
C₉H₁₁FN₂O₅ MW: 246,19 g/mol Smältpunkt: 142…155 °C Storage Temperature: Frys |
MDL Number:
MFCD00006530 CAS nummer: 50-91-9 UN: 2811 ADR: 6.1,III |
Specifikation testresultat
| Identity Test | Passes |
| Purity | ≥98% |
| FTIR | Conforms to Standard |
| Melting Point | 142 - 155 °C |
| UV/VIS: l max (water) | 266 - 270 nm |
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