3-Isobutyl-1-methylxanthine, white powder
Leverantör: MP Biomedicals
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Varning
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Synonyms:
IBMX
IBMX has been shown to be a potent, non-specific inhibitor of adenosine 3',5'-cyclic monophosphate phosphodiesterase (cAMP PDE)4, significantly more effective than theophylline. Also inhibits cGMP phosphodiesterases. IBMX inhibits cyclic nucleotide PDE with subsequent inhibition of cyclic nucleotide hydrolysis, resulting in accumulation of cyclic AMP and guanosine 3',5'-cyclic monophosphate.
IBMX helps in inhibition of phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50 = 1,3 μM). Also inhibits ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. Inhibits the growth of carcinoma cells both in vivo and in vitro in mice.
Soluble in Krebs-Henseleit bicarbonate buffer, ethanol (10 mg/ml or 25 mg/ml with sonication), DMSO (1 M with warming), or aqueous NaOH (pH 9,5); slightly soluble in water (0,3 mg/ml hot water). Solubility in 45% (w/v) aqueous 2-hydroxy-propyl-b-cyclodextrin is 3,2 mg/ml.
Observera: Research Use Only (RUO).
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Formel:
C₁₀H₁₄N₄O₂ MW: 222,25 g/mol Storage Temperature: Frys |
MDL Number:
MFCD00005584 CAS nummer: 28822-58-4 |
Specifikation testresultat
| Identity Test | Passes |
| FTIR | Conforms to Standard |
| Melting Point | 195 - 202 °C |
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