β-Dihydronicotinamide adenine dinucleotide disodium salt (NADH-Na₂, reduced form) ≥98%
Leverantör: MP Biomedicals
Synonyms:
Nicotinamide adenine dinucleotide reduced, disodium salt (reduced form), NADH disodium salt, ((2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl)methoxy-((((2R,3S,4R,5R)-5-(3-carbamoyl-4H-pyridin-1-yl)-3,4-dihydroxy-oxolan-2-yl)methoxy)hydroxyphosphoryl)oxyphosphinic acid disodium salt
White Powder, soluble in water or aqueous buffers (50 mg/ml); soluble in 0,01 N Sodium hydroxide (100 mg/ml - clear to slightly hazy, yellowish solution).
A high purity preparation of NADH suitable for most applications.
Meets or exceeds NRC specifications
β-NADH a pyridine nucleotide and biologically active form of nicotinic acid, is a coenzyme necessary for the catalytic reaction of certain enzymes.
β-Nicotinamide adenine dinucleotide and β-Nicotinamide adenine dinucleotide, reduced (NADH) comprise a coenzyme redox pair (NAD+:NADH) involved in a wide range of enzyme catalysed oxidation reduction reactions. In addition to its redox function, NAD+/NADH is a donor of ADP-ribose units in ADP-ribosylaton (ADP-ribosyltransferases; poly(ADP-ribose) polymerases ) reactions and a precursor of cyclic ADP-ribose (ADP-ribosyl cyclases). As a reagent, NADH can be used in enzyme cycling assays to amplify detection of activity of biologically relevant enzymes or metabolites present in low concentrations.
NADH is a coenzyme that functions as a regenerating electron donor in catabolic processes including glycolysis, beta-oxidation and the citric acid cycle (Krebs cycle, TCA cycle). It participates in cell signaling events as well, for example as a substrate for the poly (ADP-ribose) polymerases (PARPs) during the DNA damage response. The NAD+/NADH dependent sirtuins play key roles in stress responses during events involving energy metabolism, with implications in cancer biology, diabetes and neurodegenerative disease.
Observera: pH 7,5 - 9,5 (10% aq soln)
Store at −0 °C. Store desiccated. Protect from light. Store under nitrogen.
|
Formel:
C₂₁H₂₇N₇Na₂O₁₄P₂ MW: 709,41 g/mol |
MDL Number:
MFCD00036200 CAS nummer: 606-68-8 |
Specifikation testresultat
| Synonyms | β-NADH, 2Na; Reduced DPN; Cozymase, reduced form; Dihydrophosphopyridine nucleotide; Dihydronicotinamide adenine dinucleotide; Diphosphopyridine nucleotide, reduced form; β-DPNH; DPNH; NADH |
| Form | White Powder |
| Storage | Store at −0 °C. Store desiccated. Protect from light. Store under nitrogen. |
| pH | 7,5 - 9,5 (10% aq soln) |
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