Cytosine-β-D-arabinofuranoside hydrochloride, pulver
Leverantör: MP Biomedicals
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Varning
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Synonyms:
Arabinosylcytosine hydrochloride, Cytarabine HCI, Cytarabine HCl, 4-Amino-1-((2S,3R,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one hydrochloride, 1-(β-D-Arabinofuranosyl)cytosine HCl
Soluble in water (50 mg/ml - clear, colourless solution).
Cytosine β-D-arabinofuranoside hydrochloride is an anti-leukemic agent. It results in DNA fragmentation and inhibition of replication. In addition this compound does not have any effects on RNA synthesis. Cytosine β-D-arabinofuranoside hydrochloride can function as a ligand which shows strong affinity and selectivity for the Translocator protein (TSPO). Studies suggest that cytosine β-D-arabinofuranoside hydrochloride can down-regulate deoxycytidine kinase in acute myeloid leukemia murine cell lines which inhibits the phosphorylation of several deoxyribonucleosides. Furthermore, cytosine β-D-arabinofuranoside hydrochloride can be inhibited in myeloid leukemic cells via suppression of ENT1 promoter activity, responsible for transporting cytosine β-D-arabinofuranoside into the cell.
Cytosine β-D-arabinofuranoside hydrochloride is a selective inhibitor of DNA synthesis that does not affect RNA synthesis in mammalian cells. It is used as an antineoplastic and antiviral agent.
Ara-C an anti-leukemia agent is phosphorylated to Ara-CTP and is incorporatee into DNA. It inhibits DNA replication by forming cleavage complexes with topoisomerase I resulting in DNA fragmentation, and ultimately induces apoptosis via the PKC signaling pathway. It does not inhibit RNA synthesis.
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Formel:
C₉H₁₄ClN₃O₅ MW: 279,677 g/mol |
MDL Number:
MFCD00012839 CAS nummer: 69-74-9 |
Specifikation testresultat
| Form | White Powder |
| Storage | Store at 2 to 8 °C |
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